CARDIOPROTECTIVE EFFECT OF NICORANDIL, A MITOCHONDRIAL ATP-SENSITIVE POTASSIUM CHANNEL OPENER, PROLONGS SURVIVAL IN HSPB5 R120G TRANSGENIC MICE.

Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice.

BACKGROUND: Transgenic (TG) mice with overexpression of an arg120gly (R120G) missense mutation in HSPB5 display desmin-related cardiomyopathy, which is characterized by formation of aggresomes.It is also known that progressive mitochondrial abnormalities and apoptotic cell death occur in the hearts of R120G TG mice.The role of mitochondrial dysfunc

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Forensic investigation of a hunting incident of Indian porcupine (Hystrix indica) in Uttarakhand: A study to help rein in biodiversity loss

Across the world, hunting is one of the main causes of the decline in populations of wild vertebrates.This activity has serious effects not only on the specific, target populations but also on the dynamics and structures of other animal populations.Often the only evidence available for successful prosecution of poachers is in the form of small piec

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